| Non Linear Fit of RAW amplitudes |
|
|
|
Non
Linear Fit of Normalized |
|
|
|
|
P[sytWT] |
P[sytA-ME] |
P[sytA-ME,FE] |
|
|
P[sytWT] |
P[sytA-ME] |
P[sytA-ME,FE] |
|
| [Agonist]
vs. response -- Variable slope (four parameters) |
[Agonist] vs. normalized
response -- Variable slope |
| Best-fit
values |
|
|
|
Best-fit values |
|
|
|
| Bottom |
1.665 |
1.257 |
0.3403 |
|
HillSlope |
1.729 |
1.665 |
1.652 |
|
| Hillslope |
1.758 |
1.755 |
1.803 |
|
EC50 |
0.6286 |
0.9271 |
0.9843 |
|
| Top |
37.08 |
32.19 |
7.928 |
|
logEC50 |
-0.2016 |
-0.0329 |
-0.00689 |
|
| EC50 |
0.6663 |
1.007 |
1.05 |
|
Std. Error |
|
|
|
|
| logEC50 |
-0.1763 |
0.003072 |
0.02132 |
|
HillSlope |
0.1413 |
0.1046 |
0.1753 |
|
| Span |
35.42 |
30.94 |
7.587 |
|
EC50 |
0.03268 |
0.03583 |
0.06383 |
|
| Std. Error |
|
|
|
|
95% CI (profile
likelihood) |
|
|
| Bottom |
0.9541 |
0.7287 |
0.4123 |
|
HillSlope |
1.389 to 2.171 |
1.412 to 1.975 |
1.253 to 2.216 |
| Hillslope |
0.1803 |
0.1908 |
0.4662 |
|
EC50 |
0.5468 to 0.7171 |
0.8379 to 1.023 |
0.8288 to 1.160 |
| Top |
1.068 |
1.203 |
0.7009 |
|
logEC50 |
-0.2622 to -0.1444 |
-0.07683 to 0.009701 |
-0.08153 to 0.06436 |
| EC50 |
0.04318 |
0.06619 |
0.159 |
|
Goodness of Fit |
|
|
|
| Span |
1.624 |
1.61 |
0.9295 |
|
Degrees of Freedom |
5 |
5 |
5 |
|
| 95%
CI (profile likelihood) |
|
|
R squared |
0.9928 |
0.9954 |
0.9869 |
|
| Bottom |
-1.775 to 4.558 |
-1.304 to 3.408 |
-2.497 to 1.470 |
|
Sum of Squares |
59.24 |
35.46 |
100.6 |
|
| Hillslope |
1.214 to 2.483 |
1.195 to 2.506 |
0.3795 to 5.544 |
|
Sy.x |
3.442 |
2.663 |
4.486 |
|
| Top |
34.09 to 41.64 |
28.94 to 37.89 |
6.286 to 63.18 |
|
Constraints |
|
|
|
| EC50 |
0.5431 to 0.8277 |
0.8225 to 1.313 |
0.6581 to 377.7 |
|
EC50 |
EC50 > 0 |
EC50 > 0 |
EC50 > 0 |
|
| logEC50 |
-0.2651 to -0.08212 |
-0.08488 to 0.1183 |
-0.1817 to 2.577 |
|
|
|
|
|
|
| Goodness
of Fit |
|
|
|
Number of points |
|
|
|
| Degrees of Freedom |
3 |
3 |
3 |
|
# of X values |
7 |
7 |
7 |
|
| R squared |
0.9979 |
0.998 |
0.9889 |
|
# Y values analyzed |
7 |
7 |
7 |
|
| Sum of Squares |
2.26 |
1.589 |
0.5373 |
|
| Sy.x |
0.868 |
0.7279 |
0.4232 |
|
| Constraints |
|
|
|
| EC50 |
EC50 > 0 |
EC50 > 0 |
EC50 > 0 |
|
|
|
|
|
|
| Number
of points |
|
|
|
| # of X values |
7 |
7 |
7 |
|
| # Y values analyzed |
7 |
7 |
7 |
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